Genome genetic engineering

Strauss, S. 2003. Genomics, genetic engineering, and domestication of crops. Science 300 61—62. 

In this section, we will consider the methodologies used for genetic engineering of biocatalysts for desulfurization and the biocatalysts developed so far via various technologies. The application of genomic techniques as reported in patent literature associated with BDS is described first. 

The CRF-overexpressing mice are a genetically engineered strain with more than the normal number of copies of the CRF-encoding gene inserted in their genome. Compared with their wild-type counterpart, these animals show increased anxiety they also have some of the abnormalities seen in hypercortisolemic patients, such as adrenal hypertrophy, marked thymus involution and increased abdominal fat (Beckmann et al.. 2001). They have increased blood levels of cortisol and represent an animal model of hypercortisolemia IStenzel-Poore et al.. 1992. 1994 Holmes, 2001). 

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