Genome analysis exons

The stem-loop structure in the noncoding 3 region of selenoprotein mRNAs has also been termed a SECTS element in mammals although it has a different overall structure. ° In silica analysis of the human genome sequence, using this consensus SECTS element along with the presence of the characteristic UGA codon within an exon, has led to the discovery of several new selenoproteins, including a selenium-dependent methionine sulfoxide reductase. It has been shown that a specific complex exists for selenoprotein synthesis that shuttles between the nucleus and the cytosol. This possibly protects the preformed complex for nonsense-mediated decay to allow for more efficient selenoprotein synthesis. The specific tRNA needed for selenocysteine... 

Alternative mRNA splicing detection and analysis of human exonic enhancer sequences using genomic SELEX... 

Recently, Affymetrix also launched their exon arrays (i.e., arrays that use multiple probes to target essentially every exon of each transcript variant). This platform is the most detailed for analysis of gene expression levels, and it allows for identification of alternative splicing in addition to the standard genome-wide transcriptional analysis. 

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