Genital warts patient-applied

Beutner KR, et al. (1998) Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts. Antimicrob Agents Chemother 42(4) 789-794... 

Genital and perianal warts Apply 3 times per week to external genital/perianal warts, prior to normal sleeping hours, and leave on the skin for 6 to 10 hours. Continue imiquimod treatment until there is total clearance of the genital/perianal warts or for a maximum of 16 weeks. A rest period of several days may be taken if required by the patient s discomfort or severity of the local skin reaction. Treatment may resume once the reaction subsides. 

Systemic absorption of imiquimod was observed across the affected skin of 12 patients with genital/perianal warts, with an average dose of 4.6 mg. Mean peak drug concentration of approximately 0.4 ng/mL was seen during the study. Mean urinary recoveries of imiquimod and metabolites combined over the whole course of treatment, expressed as percent of the estimated applied dose, were 0.11% and 2.41% in the men and women, respectively. 

New option for treatment of genital and perianal warts which can be applied by patient at home and appears to have low toxicity compared to podofilox... 

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