Generation of the pulsatile signal

The analysis of the models shows that the value of the optimal frequency of stimulation is dictated primarily by the rate of receptor resensitization in the absence of ligand. For Dictyostelium amoebae, the adjustment between the period of stimulation and the refractory period is ensured by the fact that both originate from the same signalling 

Oscillatory release of GnRH could also rely on an autocrine loop involving negative (Bourguignon et al, 1994) or positive (Krsmanovic et al, 1993) feedback. The possibility of positive feedback in GnRH secretion is suggested by the presence of GnRH receptors on the surface of 

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