Generation of Stabilized Carbanions Under Basic Conditions

Generation of Stabilized Carbanions Under Basic Conditions 

For practical purposes, it would seem useful to have an overview of methods for the generation of carbanions and guidelines on compatibility with various polymers and linkers. In the following list, we summarize certain commonly used carbanions, linkers, supports, and methods of generation (Table 8). 

Entry Structure to be deprotonated Conditions Electrophile Reference 

PS-Wang resin 1. pre-swell the resin aldehydes with THF 2. add 0.1 M NaOMe in MeOH (12 equiv.) [453, 387] 

P fliTih amide various carbo-resin end beterocvcies 

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