Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Generating targeted leads

Guba W, Roche O. (2004) Computational filters in lead generation Targeting drug-hke chemotypes. In H Kubini, G Muller (eds), Chemogenomics in Drug Discovery — A Medicinal Chemistry Perspective, pp. 325-339. Wiley-VCH, Weinheim. [Pg.35]

In the second example, LEAP2 was utilized to help generate novel leads against an anti-angiogenesis target, caspase-3 (29, 30). A literature compound (PAC-1 with reported 3.1 xM IC50) and five of its analogs (31) were used as query molecules, and the product similarity threshold was set as top 50 final output molecules... [Pg.269]

Computational Filters in Lead Generation Targeting Drug-like Chemotypes... [Pg.325]

See other pages where Generating targeted leads is mentioned: [Pg.315]    [Pg.13]    [Pg.53]    [Pg.424]    [Pg.28]    [Pg.129]    [Pg.97]    [Pg.492]    [Pg.54]    [Pg.48]    [Pg.135]    [Pg.180]    [Pg.268]    [Pg.559]    [Pg.353]    [Pg.578]    [Pg.146]    [Pg.77]    [Pg.30]    [Pg.13]    [Pg.167]    [Pg.230]    [Pg.77]    [Pg.123]    [Pg.3]    [Pg.281]    [Pg.84]    [Pg.1365]    [Pg.29]    [Pg.163]    [Pg.404]    [Pg.49]    [Pg.171]    [Pg.418]    [Pg.414]    [Pg.362]    [Pg.796]    [Pg.417]    [Pg.146]   


SEARCH



Computational Filters in Lead Generation Targeting Drug-like Chemotypes

Lead Generation for Challenging Targets

Lead generation targeted kinase libraries

Leads generation

© 2024 chempedia.info