General Concepts for Derivatization of Functional Groups

As noted previously (Section 22.2), derivatization with a chiral derivatizing reagent (CDR) requires the presence of suitable functionality (e.g., —OH, Ar—OH,—SH,—COOH,—CO—NH2,—NRH) within the chiral analyte to serve as a reactive site. Before addressing specific issues with regard to CDR and analyte classes, it may be helpful to review general considerations for achiral derivatization in chromatographic assays. 

Desirable achiral derivatization reaction properties include fast, unidirectional reactions with no or minimal side reactions. In addition, both the reagent 

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