Derivatization groups

This has been particularly evident with the me thyIcarhamate and phosphoramidothioate insecticides where in almost all cases derivatization has resulted in improved mammalian toxicity. Further, in many cases, equal or greater insecticidal activity has also been observed although in some cases insecticidal activity may be substantially reduced. Improvement in mammalian toxicity has been attributed to the delayed factor provided by the derivatizing group, giving the animal the opportunity to metabolize the compound to non-toxic products. 

Derivative Structure Number of derivatized groups Increment... 

Product-ion mass spectra of protonated DMG-DAG after low-energy CID displayed only a predominant fragment ion peak at [M-l-H-103]+, corresponding to the neutral loss of DMG from the derivatized group. The product-ion ESI-MS/MS... 

Fig. 11 Separation of compounds belonging to different classes on aromatic-derivatized CF6 CSPs (Columns 25 cm, 4.6 mm i.d.). Aromatic derivatization groups (a) 3,5-dichlorophenyl carbamate (b) 3,5-bis(trifluoromethyl)phenyl carbamate (c), and (d) / -naphthylethyl carbamate. Mobile phases (A) heptane/ethanol 80/20 (b) acetonitrile/methanol/acetic acid/triethylamine 75/25/0.3/0.2 (c) heptane/isopropanol/trifluoroacetic acid 98/2/0.1 (d) acetonitrile/methanol 40/60 with 25 mM ammonium nitrate. All mobile phases in % v/v and used at 1 mL/min flow rate. UV detection 254 nm...

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