Gene transfer into islet cells

The ability to transfer genes into islets and perhaps the insulin producing fl cells appears to represent an excellent opportunity to utilize gene therapy for improving the clinical efficacy of islet cell transplantation. Unlike the case of other organ transplants 

ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY 

Examples of candidate transgenes with potential utility in the prevention of islet transplant rejection 

T cell activation CTLA4-Ig Heart, liver, and pancreas Prolonged allograft survival Olthoff et al. (1998) Uchikoshi et al. (1999) Yangs et al. (1999) 

Cell death, apopto- MnSOD in NOD mice (J. in IFN-y and j in TGF-/J at the transplant site) Insulinoma cells Protection against IL-1 ji Hohmeier et al. (1998) 

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