Gene products, diseases associated with

This table indicates the chromosomal location of several genes and the diseases associated with deficient or abnormal production of the gene products. The chromosome involved is indicated by the first number or letter. The other numbers and letters refer to precise localizations, as defined in McKusick VA Mendelian Inheritance in Man, 6th ed. John Hopkins Univ Press, 1983. 

Variants of the ABCB1 gene have been associated with a diverse number of diseases and with a great variety of drugs, natural products, and endogenous agents (see Table 5) [687],... 

Banning patents on particular kinds of products or processes, such as patents on genes that are associated with diseases or patents on genetic tests [23]. 

Given the role of H. pylori infection in gastric cancer and duodenal ulcer disease, one must note that certain interleukin-1 gene cluster polymorphisms (suspected of increasing production of interleukin-1-/1) are associated with a predisposition to hypochlorhydria and gastric cancer [52]. One of these host DNA polymorphisms involves a TATA box. 

Various disease states are associated with the inappropriate production/overproduction of gene products. Examples include ... 

A more detailed understanding of the biochemical pathways and enzymes involved in saponin biosynthesis will facilitate the development of plants with altered saponin content. In some cases, enhanced levels of saponins or the synthesis of novel saponins may be desirable (for example, for drug production 4 or improved disease resistance3,5,6), while for other plants, reduction in the content of undesirable saponins would be beneficial (for example, for legume saponins that are associated with antifeedant properties in animal feed7). This chapter is concerned with recent progress that has been made in the characterization of the enzymes and genes involved in the synthesis of these complex molecules and focuses on triterpenoid saponins. 

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