Myositis gemfibrozil

Gemfibrozil 600 mg tablets 1200 mg/day in two doses, 30 minutes before meals abdominal pain, and rash. Increased risk of rhabdomyolysis when given with a statin. Fibric acids are associated with gallstones, myositis, and hepatitis. 

Regimens intended to increase HDL levels should include either gemfibrozil or niacin, bearing in mind that statins combined with either of these drugs may result in a greater incidence of hepatotoxicity or myositis. 

In 80 patients with primary mixed hyperlipidemia, gemfibrozil used together with lovastatin resulted in 3% discontinuation because of myositis, but none attributable to rhabdomyolysis or myoglobinuria (72). 

Chow LT, Chow WH. Acute compartment syndrome an unusual presentation of gemfibrozil induced myositis. Med J Aust 1993 158(l) 48-9. 

Musculoskeletal Myositis has been described in a patient with normal renal function taking gemfibrozil monotherapy [IS ]. 

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