Gelatin production, lipase

Oral pancreatic enzyme supplements are available as powders, uncoated or coated tablets, capsules, enteric-coated spheres and microspheres, or enteric-coated microtablets encased in a cellulose or gelatin capsule (Table 28-2). Microencapsulated enteric-coated products are not superior to recommended doses of conventional non-enteric-coated enzyme preparations. The quantity of active lipase delivered to the duodenum appears to be a more important determinant in pancreatic enzyme replacement therapy than the dosage form. GI side effects appear to be dose related but occur less frequently with enteric-coated products. 

Oral pancreatic enzyme supplements are available as a powder, uncoated or coated tablet, capsule, enteric-coated sphere (ECS) and microsphere (ECMS), or enteric-coated microtablet (ECMT) encased in a cellulose or gelatin capsule (Table 39-8). Recommended dosages of microencapsulated enteric-coated products are not necessarily more effective than recommended dosages of the non-enteric-coated enzyme preparations. This is because a lesser quantity of lipase is usually administered at each meal with the enteric-coated preparations. 

Staling of bakery products is retarded by lipase, presumably through the release of mono- and di-acylglycerols (cf. 15.4.4). The defatting of bones, which has to be carried out under mild conditions in the production of gelatin, is facilitated by using lipase-catalyzed hydrolysis. 

---