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GDla, brain ganglioside

FIGURE 16.3 The major brain gangliosides GDla and GTlb. [Pg.817]

The low abundance of GQlba and the other a-series gangliosides (O.Smgkg of brain) compared with the major brain ganglioside GDla (1200mgkg ) prompted several synthetic efforts. The first total synthesis on a milligram scale was achieved in 1995 by Kiso et al. [29c]. [Pg.817]

Fig. 3 The brain gangliosides GDla (1), GTlb (2), GTlaa (3), and GQlba (4)... Fig. 3 The brain gangliosides GDla (1), GTlb (2), GTlaa (3), and GQlba (4)...
Changes in brain ganglioside expression have been documented in patients with Alzheimer s disease. Compared with control brains, patients with early onset (type I) Alzheimer s disease exhibited an increase in GD3 and GMl and a decrease in GDla and GTlb. Impaired ganglioside synthesis has also been noted with Huntington s disease. It has been suggested... [Pg.98]

Sturgill ER, Aoki K, Lopez PH, et al. Biosynthesis of the major brain gangliosides GDla and GTlb. Glycohiology. 2012 22(10) 1289-1301. [Pg.106]

Thy-l glycolipids had different TLC Rf values in solvent 1 and solvent 2. The mobility of brain Thy-l glycolipids was very similar to Gq3 ganglioside in that they migrated ahead of Gjji in solvent 2, and behind G i and slightly ahead of GDla in solvent... [Pg.457]


See other pages where GDla, brain ganglioside is mentioned: [Pg.38]    [Pg.264]    [Pg.421]    [Pg.816]    [Pg.816]    [Pg.817]    [Pg.1676]    [Pg.807]    [Pg.807]    [Pg.808]    [Pg.292]    [Pg.156]    [Pg.156]    [Pg.156]    [Pg.46]    [Pg.96]    [Pg.96]    [Pg.112]    [Pg.119]    [Pg.294]    [Pg.2108]    [Pg.2110]    [Pg.226]    [Pg.40]    [Pg.259]    [Pg.260]    [Pg.273]    [Pg.140]    [Pg.167]    [Pg.1687]    [Pg.479]    [Pg.182]    [Pg.46]    [Pg.64]    [Pg.95]    [Pg.97]    [Pg.281]    [Pg.295]    [Pg.344]    [Pg.1451]    [Pg.1453]   
See also in sourсe #XX -- [ Pg.808 ]




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