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Gastrointestinal Toxicity Reasons for Poor Translation from Animal to Human

2 Gastrointestinal Toxicity Reasons for Poor Translation from Animal to Human [Pg.273]

ANIMAL MODELS OF DISEASE FOR FUTURE TOXICITY PREDICTIONS [Pg.274]

TABLE 18 J GI Tract Major Anatomical and Functional Differences between Humans and Rats [Pg.274]

Stomach Proximal stomach Lined by stratified squamous epithelium No forestomach [Pg.274]

Ability to secrete acid in proximal (known as forestomach in rodents) No (forestomach) Yes [Pg.274]



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Animal toxicity

Animals humans

From toxicants

Gastrointestinal toxicity

Human animal toxicity

Human toxicity

Poore

Reasoning animal

Reasons for

Toxicity to Animals

Toxicity to humans

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