Gastric emptying time, alteration

Figure 26-3. Patients with severe pancreatic exocrine insufficiency (n = 14, mean + SE) show marked alterations of gastrointestinal functions with shortened small bowel transit time, 90% gastric emptying time, and duration of the fed pattern. These alterations are corrected by enzyme replacement therapy ( P <. 05 vs. controls, P <. 05 vs. placebo) (Layer et al., 1997).

Increase or decrease in rate but not extent of absorption, probably by altering gastric emptying time. ... 

Not understood. Metoclopramide alters both the gastric emptying time and gastrointestinal motility, which can affect quinidine absorption. 

Because drugs are often taken orally at the same time, the GI tract is a relatively common site for drug interactions to occur. Possible interactions during absorption include changes in local pH (e.g., antacids), altered gastric emptying and intestinal motility, and the formation of complexes. 

In a study using paracetamol (acetaminophen) as a marker of gastric emptying, pramlintide increased the time to maximum plasma paracetamol levels by up to 72 minutes and reduced the maximum paracetamol level by about 29%, without altering the overall extent of absorption. This effect was seen when paracetamol was given simultaneously with pramlintide, or for up to two hours after pramlintide. It was not seen when paracetamol was given one to two hours before pramlintide. ... 

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