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Gastric acid pump

Pharmacology These agents have been characterized as gastric acid pump... [Pg.1386]

Pope, A.J. ef al. (1993) Reversible inhibitors of the gastric H /K -transporting ATPase A new class of anti-secretory agent. Trends Pharmacol. Sc/., 14. 323-325. Sachs. G. et al. (1995) The pharmacology of the gastric acid pump The H. K ATPase. Anna. Rev. Pharmacol. Toxicol.. 35. 277-305. [Pg.42]

Sachs, G. etal. (1995) The pharmacology of the gastric acid pump The H+.K+ ATPase. Annu. Rev. Pharmacol. Toxicol., 35. 277-305. [Pg.130]

Omeprazole belongs to a new class of antisecretory compounds, the snbstitnted benzimidazoles, that do not exhibit anticholinergic or H2-histamine-antagonistic properties bnt suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory snrface of the gastric parietal cell. Because this enzyme system is the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid pump inhibitor it blocks the final step of acid prodnction. This effect is dose-related, and inhibits both basal and stimnlated acid secretion irrespective of the stimnlns. [Pg.516]

Structural changes of the gastric acid pump and transport... [Pg.37]

The three-dimensional structure of the gastric acid pump is based on the structure of the SR Ca ATPase, and there is sufficient difference in detail that this structure, although highly informative as to mechanism, cannot provide a template for design of specific inhibitory ligands. Design of the PPIs does not depend on details of molecular structure, because these are chemical in concept, rather than biologic. [Pg.144]

Reaction of PPIs with the isolated ATPase resulted in inhibition of the ATPase only under acid-transporting conditions. This was found for all of the PPIs. Inhibition by omeprazole was reversed by mercaptoethanol or dithiothreitol, also showing that disulfide formation was responsible for inhibition of the gastric acid pump. [Pg.152]

The PPIs as a class are acid-unstable drugs, an essential property to ensure targeting to the active gastric acid pump. This therefore limits their usefulness in oral therapy, where the standard enteric formulation has been dissolved to... [Pg.310]

Section 1 The Production of Acid in the Stomach Chapter 1 The Discovery of Acid Chapter 2 The Discovery of Ion Pumps Chapter 3 Ion-Motive Adenosine Triphosphatases Chapter 4 The Gastric Acid Pump... [Pg.532]

Chapter 1 History of Therapeutic Approaches to Acid Related Diseases Chapter 2 Inhibition of the Histamine-2 Receptor Chapter 3 Inhibition of the Gastric Acid Pump Section 4 The Biology of Acid Related Disease... [Pg.532]

Figure 1. A general model of the sodium and gastric acid pumps identifying their domains and their two subunits. The cytoplasmic domain binds ATP, becomes phosphorylated and releases ADP and Pi. The stalk transduces the conformational change due to phosphorylation/dephos-phorylation to the membrane domain which contains the ion transport pathway, binding Na or H with high affinity (ion in ) in one conformational state, and with low affinity in a second conformational state (ion out ) [7]. Figure 1. A general model of the sodium and gastric acid pumps identifying their domains and their two subunits. The cytoplasmic domain binds ATP, becomes phosphorylated and releases ADP and Pi. The stalk transduces the conformational change due to phosphorylation/dephos-phorylation to the membrane domain which contains the ion transport pathway, binding Na or H with high affinity (ion in ) in one conformational state, and with low affinity in a second conformational state (ion out ) [7].
Sachs G, Shin JM, Besancon M, Prinz C (1993) The continuing development of gastric acid pump inhibitors (lansoprazole). Aliment Pharmacol Ther 7 (Suppl 1) 4-12... [Pg.44]

See other pages where Gastric acid pump is mentioned: [Pg.116]    [Pg.127]    [Pg.133]    [Pg.84]    [Pg.12]    [Pg.23]    [Pg.143]    [Pg.143]    [Pg.212]    [Pg.308]    [Pg.474]    [Pg.37]    [Pg.41]    [Pg.66]   
See also in sourсe #XX -- [ Pg.24 ]



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