Gas Phase Hydrogen-Deuterium Exchange

Deuterium and other isotopic labeling prior to mass spectrometric analysis has been known from the early days of mass spectrometry (Chaps, 2,9 and 3,3), Modem methodology even allows labeling of gaseous ions, thereby yielding insight 

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Hofstadler, S.A. Sannes-Lowery, K.A. Griffey, R.H. Enhanced Gas-Phase Hydrogen-Deuterium Exchange of Oligonucleotide and Protein Ions Stored in an External Multipole Ion Reservoir. J. Mass Spectrom. 2000, 55, 62-70. 

Gas-Phase Hydrogen/Deuterium Exchange in Quadrupole-lon Traps... 

Chipuk, J.E. Brodbelt, J.S. Investigation of the gas-phase hydrogen/deuterium exchange behavior of aromatic dicarboxylic acids in a quadrupole ion trap. Int. J. Mass Spectrom. 2007, 267, 98-108. 

Gard, E. Grenn, M.K. Bregar, J. Lebrilla, C.B. Gas-phase hydrogen/deuterium exchange as a molecular probe for the interaction of methanol and protonated peptides. J. Am. Soc. Mass Spectrom. 1994, 5, 623-631. 

Evans, S.E. Lueck, N. Marzluff, E.M. Gas-phase hydrogen/deuterium exchange of proteins in an ion trap mass spectrometer. Int. J. Mass Spectrom. 2003, 222, 175-187. 

Zhang, J. Brodbelt, J.S. Gas-phase hydrogen/deuterium exchange and conformations of deprotonated flavonoids and gas-phase acidities of flavonoids. J. Am. Chem. Soc. 2004, 126,5906-5919. 

Kaltashov, I.A. Doroshenko, V.M. Cotter, R. J. Gas phase hydrogen/deuterium exchange reactions of peptide ions in a quadrupole ion trap mass spectrometer. Proteins Struct. Funct. Genet. 1997, 28, 53-58. 

Freitas, M.A. Hendrickson, C.L. Emmett, M.R. Marshall, A.G. High-Field Fourier transform ion cyclotron resonance mass spectrometry for simultaneous trapping and gas phase hydrogen/deuterium exchange of peptides. J. Am. Soc. Mass Spectrom. 1998, 9, 1012-1019. 

Rand, K.D., Pringle, S.D., Morris, M., Brown, J.M. (2012) Site-specific analysis of gas-phase hydrogen/ deuterium exchange of peptides and proteins by electron transfer dissociation. Analytical Chemistry, 84(4), 1931-1940. 

ESI Study of gas-phase hydrogen/deuterium exchange (ubiquitin) Freitas et al. [237]... 

Green-Church KB, Limbach PA, Freitas MA, Marshall AG (2001) Gas-phase hydrogen/ deuterium exchange of positively charged mononucleotides by use of Fourier-transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom 12 268-277. doi 10.1016/ 81044-0305(00)00222-1... 

Campbell, S. Rodgers, M. T. Marzluff, E. M. Beauchamp, J. L. Structural and energetic constraints on gas phase hydrogen/deuterium exchange reactions of protonated peptides with D2O, CD3OD, CD3CO2D, and ND3. J. Am. Chem. Soc. 1994, 116, 9765-9766. 

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