Garlic, absorption metabolism

There are only a few reports on the absorption, metabolism, and excretion of garlic s sulfur compounds available. Further, until now it is not known what metabolic form of allicin actually reaches the target cells, and it is still unknown how garlic compounds might function in the body. 

Human clinical studies Allicin is well absorbed, as indicated by a persistent garlicky odor on the breath, skin, and amniotic fluid of persons after consumption of fresh garlic (83). Because oral comsumption of pure allicin has been shown to significantly increase overall body catabolism of triglycerides, a substantial absorption of allicin is assumed to occur (84). However, the metabolic fate of allicin in the body is not well understood. 

The human metabolism of these sulphur compounds is complex and far from understood. Moreover, due to the complexity and number of potential products, it is difficult to generalize. Several compounds probably conjugate with glutathione post-absorption, and are metabolized via the mercapturic acid pathways, in a similar manner to isothiocyanates. N-acetyl-S-aUyl-L-cysteine (allylmercapturic acid), derived from diallyl disulphide, has been detected in urine from humans who have consumed garlic (de Rooji et al. 1996). The characteristic breath and perspiration odours foimd following garlic consumption are... 

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