Garcinol radical scavenging activity

Krishnamurthy [73] observed that garcinol had no antioxidative activity in lipid peroxidation. Yamaguchi et al. evaluated the chelating, antioxidative and radical scavenging activities of garcinol, demonstrating that it has a strong antioxidant activity [59,60],... 

In the DPPH (l,l-diphenyl-2-picrylhydrazyl) assay, garcinol exhibited potent radical scavenging activity at an extent almost 3 times higher than a-tocopherol and comparable to 85% of the activity of ascorbic acid [84],... 

The radical scavenging activity of garcinol have been confirmed using the electron spin resonance (ESR) spin trapping method which observe the reaction between superoxide anion and radical scavenger more directly. 

This results confirmed that scavenging activity of garcinol against hydroxyl radical was stronger than that a-tocopherol and its other scavenging activities were weaker. 

In the Fenton reaction system, garcinol suppressed hydroxyl radical formation, dose-dependently, more strongly than a-tocopherol and catechin [59]. The suppression of hydroxyl radical in this system may be caused by direct scavenge but also by inhibition of the Fenton reaction by Fe2+ chelation for chelating activity of garcinol. 

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