Gamma-aminobutyric acid neurons producing

In simple terms, messages travel along neurons (nerve cells) in the form of an electrical current that moves from one end of the neuron to its opposite end. The electric current is produced by a flow of sodium ions (Na ") and potassium ions (K ) across the nerve membrane, as shown in the diagram on page 11. When the electrical current reaches the end of the neuron, it causes the release of a chemical known as a neurotransmitter. Some examples of neurotransmitters are acetylcholine, serotonin, dopamine, GABA (gamma-aminobutyric acid), and norepinephrine. 

Phenobarbital is the most commonly used anticonvulsant in horses as it has effects at doses lower than those that produce sedahon. It potentiates the actions of gamma-aminobutyric acid (GABA), the inhibitory neurotransmitter in the CNS. Neuronal stabilization by GABA in postsynaptic neurons occurs from increased intracellular chloride conductance, which hyperpolarizes the membrane the overall result is an increase in the seizure threshold and a decrease in the electrical activity of the seizure focus. 

I. Mechanism of toxicity. The growth of C tetani in a wound under anaerobic conditions produces the toxin tetanospasmin. The toxin enters the myoneural junction of alpha motor neurons and travels via retrograde axonal transport to the synapse. There it biocks the release of the presynaptic inhibitory neurotransmitters gamma-aminobutyric acid (GABA) and glycine, causing intense muscular spasms. 

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