Galactosyltransferase Family

Schwientek, T., Almeida, R., Levery, S.B., Holmes, E.H., Bennett, E. and Clausen, H. Cloning of a novel member of the UDP-galactose P-N-acetylglucosamine pi,4-galactosyltransferase family, p4Gal-T4, involved in glycosphingolipid biosynthesis. J. Biol. Chem. 1998, 273, 29331-29340. 

Uridine diphosphate galactose lactosylceramide galactosyltransferase activity in cultured normal and familial hypercholesterolemic human fibroblasts... 

Galactosyltransferases are a family of enzymes that catalyze the addition of a galactose residne from activated sngar nncleotide donor nridine diphosphate galactose (UDP-Gal) to different acceptor snbstrates in different finks. 

Bennett EP, Clausen H. Cloning and expression of a proteoglycan 80. UDP-galactose P-xylose 31,4-galactosyltransferase I - A seventh member of the human 34-galactosyltransferase gene family. J. 

Figure 3 Representative structures for GT-A and GT-B folds. GT-A Family 2, SpsA enzyme from Bacillus subtilis (PDB 1QG8) GT-B Family 8, a-galactosyltransferase LgtC from Neisseria meningitidis 126E (PDB 1G9R).

A family of homologous p3-galactosyltransferase genes encoding enzymes that transfer to GlcNAc and to GalNAc has been identified recently [14], but the Core 1 Gal transferase has not yet been cloned. 

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