Gabriel extended

The Gabriel s synthesis has been further extended to alkoxythiazoles. Thus 2-alkoxy (or aryloxymethyl) 5-methyl (or phenyl) thiazoles (200) were prepared by refluxing the corresponding acylaminoketone (199) in dry pr3ridine in the presence of P2S5 (Scheme 105) (409). 

The reaction of ethylenimine with carbon disulfide to give ilitn-thiazolidoue wae discovered by Gabriel and later extended to other azitidineas. (Eq, 66). 

Gabriel ethylenimine method. Formation of ethylenimines (aziridines) by elimination of hydrogen halides from aliphatic vicinal haloamines with alkali. The method can be extended to the preparation of five- and six-membered ring amines. 

J.-C.P. Gabriel, F. Camerel, B.J. Lematre, H. Desvaux, P. Davidson, P. Betail, Swollen liquid-crystalline lamellar phase based on extended solid-like sheets. Nature 413, 504-508 (2001)... 

Also, special thanks to my fcimily — my husband Gabriel Rothman, my mother Michele Gcirber, my father Jeffrey Racow, my stepmother Sue Racow, and my stepfather Alan Garber. 1 also want to thank my sister Kim Racow—even though she is so far away in Africa, she is edways in my heart. Thanks also go to my extended family, Jeff and Kathy Rothman, Stacey Rothman, Loren Rothman, and Toni Sicola. 

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