Gabapentin lorazepam

Gabapentin (Neurontin) Lamotrigine (Lamictal) Levetiracetam (Keppra) Lorazepam (Ativan, others)... 

Although phenothiazines, clonidine, carbamazepine, y-hydroxybutyric acid, and valproic acid may reduce symptoms of alcohol withdrawal, their ability to prevent seizures or delirium tremens has yet to be proven, and in fact, the phenothiazines may lower the seizure threshold. Other drugs used to treat symptoms of alcohol withdrawal include other barbiturates, alcohol itself, sympatholytics such as atenolol, thiamine, magnesium, and other neuroleptics such as haloperidol. At the time of this writing, gabapentin is being compared to lorazepam for acute alcohol withdrawal in a phase II clinical trial. 

Pharmacologic treatment of RLS includes dopaminergic agents, benzodiazepines, opioids, or anticonvulsants. In mild cases of RLS, benzodiazepines may be first-line agents. Clonazepam, lorazepam, triazolam, and temazepam have been effective. Clonazepam 0.5 to 2 mg is most frequently studied. Opiates such as methadone 5 to 20 mg, codeine 30 to 120 mg, and oxycodone 2.5 mg are very effective, but the development of tolerance is a concern. Abuse potential with opiates is also a concern due to the chronic nature of the condition. Other agents that have been used include apomorphine, amantadine, tramadol, magnesium, oxycodone, propoxyphene, gabapentin, bromocriptine, clonidine, and carbamazepine. Tolerance may de-... 

Barbiturates phenobarbital, secobarbital Benzodiazepines alprazolam, diazepam, lorazepam, triazolam Others buspirone, zolpidem BZ receptor antagonist flumazenil Carbamazepine, ethosuximide, valproic acid, phenytoin, clonazepam, diazepam, lorazepam, gabapentin... 

There appears to be no pharmacokinetic interaction between pregabalin and carbamazepine, gabapentin, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, alcohol, lorazepam, or oxycodone. However, the impairment of cognitive and gross motor function caused by oxycodone was additive with pregabalin, and pregabalin may potentiate the effects of alcohol and lorazepam. 

A 30-year-old woman taking nevirapine, saquinavir 1.2 g daily and ritonavir 600 mg daily with undeteetable viral load had her epilepsy med-ieation ehanged from gabapentin and lorazepam to lamotrigine and phenytoin beeause of inereased frequeney and severity of seizures. She required phenytoin 8 mg/kg daily to maintain therapeutie serum levels. The ritonavir dose was doubled and the saquinavir dose inereased to 2 g daily to eompensate for the enzyme-indueing efifeets of phenytoin. The patient s viral load remained undeteetable, and her seizures deereased over the next 6 months but she died suddenly of unexplained causes following a tonic-elonie seizure (autopsy not performed). ... 

Myrick H, Malcolm R, Randall PK, Boyle E, Anton RE, Becker HC, Randall CL. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res 2009 33(9) 1582-8. 

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