GABAb receptors structures

Bowery NG (2000) GABAb receptors structure and function. In Martin DL, Olsen RW (eds) GABA in the nervous system the view at fifty years. lippincott Williams and Wilkins, Philadelphia, PA, pp 233-244... 

Fig. 1. Chemical structures of ligands used to characterize, clone, and purify the GABAb receptor. The recently identified positive allosteric modulators CGP7930 and CGP 13501 are expected to broaden the spectrum of therapeutic applications for GABAb drugs.

The discovery of GABAb receptor genes from 1997 to 1998 has not only yielded new insights into the structural and functional properties of G protein coupled recep-... 

Structural and Functional Diversity Between Presynaptic and Postsynaptic GABAb Receptors... 

GABAB1(a) exhibit different structural properties that would favor interactions with multiple auxiliary proteins (Blein et al. 2004), thus generating GABAb receptor heterogeneity. 

Bettler B, Kaupmann K, Mosbacher J, Gassmann M (2004) Molecular structure and physiological functions of GABAb receptors. Physiol Rev 84 835-67... 

Bischoff S, Leonhard S, Reymann N et al (1999) Spatial distribution of GABAb R1 receptor mRNA and binding sites in the rat brain. J Comp Neurol 412 1-16 Blein S, Ginham R, Uhrin D et al (2004) Structural analysis of the complement control protein (CCP) modules of GABAb receptor la. J Biol Chem 279 48292-306 Bockaert J, Pin J-P (1999) Molecular tinkering of G-protein-coupled receptors an evolutionary success. EMBO J 18 1723-9... 

Figure 14. Structures of potent GABAb receptor antagonists...

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