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GabaA subunit composition effects

Figure 11.10 Glycine receptor pharmacology and structure, (a) Amino acids that act as agonists at glycine receptors, and strychnine a competitive antagonist, (b) Subunit composition of foetal and adult glycine receptors in the spinal cord. The receptors are shown with a pentameric assembly but the a. and subunits are distinct from those that form GABAa receptors. Picrotoxin is also an effective glycine antagonist and in recombinant systems is selective for homomeric receptors... Figure 11.10 Glycine receptor pharmacology and structure, (a) Amino acids that act as agonists at glycine receptors, and strychnine a competitive antagonist, (b) Subunit composition of foetal and adult glycine receptors in the spinal cord. The receptors are shown with a pentameric assembly but the a. and subunits are distinct from those that form GABAa receptors. Picrotoxin is also an effective glycine antagonist and in recombinant systems is selective for homomeric receptors...
Despite their efficacy in a variety of pathologic anxiety syndromes, the benzodiazepines are not perfect anxiolytics. Such a hypothetical agent would selectively ameliorate anxiety without inducing other behavioral effects. Future efforts to enhance the efficacy of benzodiazepine anxiolytics may depend on a greater understanding of the heterogeneity of the GABAa receptor—for example, which specific clinical actions (anxiolytic, muscle relaxation, sleep facilitation) reside with which specific subunit composition. [Pg.914]


See other pages where GabaA subunit composition effects is mentioned: [Pg.276]    [Pg.407]    [Pg.408]    [Pg.88]    [Pg.90]    [Pg.762]    [Pg.333]    [Pg.646]    [Pg.912]    [Pg.918]    [Pg.484]    [Pg.722]    [Pg.522]    [Pg.484]   
See also in sourсe #XX -- [ Pg.88 , Pg.89 , Pg.90 , Pg.113 , Pg.114 ]




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Compositional effect

GabaA

GabaA subunits

Subunit composition

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