G12 subfamily

The G12 subfamily has been implicated in such cellular processes as reorganization of the cytoskeleton, activation of the c-Jun N-terminal protein kinase (see Section 10.2.2), and stimulation of Na+/ H+ exchange. Activation by thromboxane and thrombin receptors has been described for members of the G12 subfamily. Examples of effector molecules include nucleotide exchange factors for Rho proteins and the GTPase-activat-ing protein Ras-GAP (see Section9.5). 

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