FXR agonists

A pharmacophore model for FXR agonists based on 14 bile acid derivatives was reported by Ekins et al. The hypothesis consisted of three H features and one H BA - a common functionality pattern among steroidal compounds [42],... 

Scheme 14.13 FXR agonists generated by combinatorial solid- and solution-phase chemistry.

K.C. Nicolaou, R.M. Evans, A.J. Roecker, R. Hughes, M. Downes, J.A. Pfefferkorn, Discovery and optimization of non-steroidal FXR agonists from natural product-like... 

FXR agonists identified from natural product-like libraries of benzopyrans... 

FIGURE 1.11 Discovery of FXR agonists from screening a benzopyran natural product-like library. 

Nicolaou, K.C. et al.. Discovery and opthnization of non-steroidal FXR agonists from natural product-hke libraries, Org. Biomol Chem., 1, 908, 2003. 

Nicolaou, K.C. et al.. Discovery of novel antibacterial agents active against methiciUin-resistant Staphylococcus aureus from combinatorial benzopyran libraries, ChemBioChem., 2, 460, 2001. Nicolaou, K.C. et al.. Discovery and optimization of non-steroidal FXR agonists from natural productlike libraries, Org. Biomol. Chem., 1, 908, 2003. 

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