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Fused proteins interleukin

A. General description Denileukin dif-titox is a recombinant, DNA-derived, interleukin-2 receptor specific ligand, cytotoxic fusion protein consisting of diphtheria toxin fragments A and B fused to interleukin-2. It is produced by expression of a recombinant fusion protein in Escherichia coli that contains nucleotide sequences for human interleukin-2, and sequences for the enzymatically active fragment A of diphtheria toxin and the membrane-translocating portion of diph-... [Pg.201]

Figure 1 depicts the schematic structures for several different types of recombinant toxins. In proteins composed of growth factors fused to toxins, a ligand, such as interleukin 2, is fused to the amino terminus of truncated PE or... [Pg.216]

See other pages where Fused proteins interleukin is mentioned: [Pg.56]    [Pg.692]    [Pg.171]    [Pg.269]    [Pg.33]    [Pg.111]    [Pg.217]    [Pg.49]    [Pg.10]    [Pg.509]    [Pg.273]   
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