Fusarentin 6,7-dimethyl ether

The asymmetric total synthesis of fusarentin 6-methyl ether, a natural isocoumarin derivative, is achieved in nine steps with 20.5% overall yield. This compound is also the key intermediate in the total synthesis of fusarentin 6,7-dimethyl ether, 7-O-demethylmonocerin and monocerin with 16.5,12.9% and 12.5% overall yields, respectively (13JOC6338). 

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