Further Relationships with Glutathione

Factors Affecting Blood Levels of Ascorbic Acid and Glutathione 

Stewart et al. (1953) have recently found that both injected ACTH and cortisone acetate given by mouth produce, in normal human subjects, a temporary disappearance of dehydroascorbic acid from the blood and its replacement by reduced ascorbic acid. This suggests the encouragement, rather than the suppression, of active reducing mechanisms such as glutathione. Further literature on this topic is mentioned under Section XI, 7. 

Ascorbic Acid and Tuberculin-SensitwUy in Guinea Pigs 

The question of the effect of ascorbic acid on adrenocortical hormone production has proved hard enough (see Section XI) the question of the influence of adrenocortical hormones on ascorbic acid metabolism seems likely to be still more difficult. 

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