Tobramycin Furosemide

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

Noninterfering acetaminophen, allopurinol, amikacin, amoxapine, amytal, bretylium, caffeine, carbamazepine, carisoprodol, chloramphenicol, chlordiazepoxide, chlorpropamide, clonazepam, codeine, diazepeun, disop30 amide, droperidol, ethinamate, ethinamate, etho-suximide, fluphenazine, flurazepam, furosemide, gentamicin, haloperidol, hydrochlorothiazide, hydro yzine, ibuprofen, kanamycin, lidocaine, loxapine, meperidine, mepho-barbital, meprobamate, methaqualone, methotrexate, morphine, nafcUlin, naloxone, neomycin, perphenazine, phenacetin, phenobarbital, phenytoin, prazepam, primidone, procaine, propoxyphene, reserpine, salicylamide, salicylic acid, secobarbital, spironolactone, theophyUine, thiopental, thioridazine, tobramycin, valproic acid, verapeunil... 

A study assessing the risk factors for nephrotoxicity with aminoglycosides (tobramycin and gentamicin) enrolled 1489 patients, 157 of whom developed clinical nephrotoxicity. Of these patients 118 had no immediately identifiable cause (such as acute renal failure) and further evaluation of other risk factors found that the concurrent use of furosemide significantly increased the risk of nephrotoxicity. A clinical study evaluating a possible interaction found that furosemide increased aminoglycoside-... 

Kaka JS, Lyman C, Kilarski DJ. Tobramycin-furosemide interacticm. DrugIntellCUnPharm (1984)18,235-8. 

Intravenous 50 mg weekly Phenoxymethylpenicillin 250 mg on alternate days Dermatomyositis (also treated with prednisone and prostatic cancer treated with diethylstilbestrol (stilboestrol) also treated with furosemide) Methotrexate toxicity within week of starting phenoxymethylpenicillin treated with folinic acid and fluid replacement (and nafcillin and tobramycin) 9... 

Noninterfering amikacin, aztreonam, carbamazepine, cephalosporins, ciprofloxacin, clavulanic acid, difloxacin, digitoxin, digoxin, fleroxacin, fosfomycin, furosemide, gentamicin, imipenem, lidocaine, netilmicin, norfloxacin, ofloxacin, pefloxacin, penicillins, phenobarbital, phenytoin, primidone, procainamide, quinidine, rifampin, salicylic acid, teicoplanin, theophylline, tobramycin, valproic acid, vancomycin... 

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