Fungus Cephalosporium aphidicolia

Deslongchamps and coworkers [26] used a combination of a transannular Diels-Alder cycloaddition and an intramolecular aldol reaction in the synthesis of the unnatural enantiomer of a derivative of the (+)-aphidicolin (4-74), which is a diterpe-noic tetraol isolated from the fungus Cephalosporium aphidicolia. This compound is an inhibitor of DNA polymerase, and is also known to act against the herpes simplex type I virus. In addition, it slows down eukaryotic cell proliferation, which makes it an interesting target as an anticancer agent... 

Aphidicolin (148), a diterpene tetraol, isolated from the fungus Cephalosporium aphidicolia Fetch, is an antibiotic that shows strong significant antiviral and antitumor activity [63,64]. The principal problem in the synthesis of aphidicolin (148) consists in the construction of tetracyclic ring system with the appropriate stereochemistry of the C/D... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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