Fungal CYPs

chrysoporium has many more for a fungal species (http //drnelson.utmem.edu/nelsonhomepage. html). 

There is interest in using fungi in bioremediation and one of those that has been used commercially is the white-rot fungus P. chrysosporium. This is a basidiomycete, higher fungus with about 

Purification of fungal CYPs from cell extracts is a difficult task due to the usual low specific content, instability, and the presence of multiple forms. The fungal steroid hydroxylase CYPs have been studied and a polycyclic aromatic hydrocarbon hydroxylase . The emergence of genomes and the ability to express the CYPs present in 

coli or yeast has greatly facilitated their study, as will the application of transcription profiling. 

Other fungal CYP families identified include a benzoate para-hydroxylase from Aspergillus niger and a cycloheximide inducible CYP54 from 

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Azoles inhibit 14-a-sterol demethylase, a microsomal CYP that is essential for ergosterol biosynthesis (Figure 48-1). This results in the accumulation of 14-a-methylsterols that disrupt the packing of acyl chains of phospholipids and impair the functions of membrane-bound enzymes such as ATPase and those of the electron transport system, resulting in inhibited fungal growth. 

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