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Functional periphery activities against

A benzodiazepine template was also reported by researchers at GlaxoSmithKline [85]. The lead molecule GW405212, (40), was identified from a 1,296-member library of 1,4-benzodiazepines prepared on Tentagel beads and screened initially in pools of 30 against CHO cells expressing the human oxytocin receptor. It is a highly potent inhibitor of oxytocin binding with a K of 8nM [86]. However, all attempts to improve the pharmacokinetic properties of this molecule were unsuccessful. It appears that the functionality responsible for the oxytocin activity is distributed around the periphery... [Pg.356]

See other pages where Functional periphery activities against is mentioned: [Pg.357]    [Pg.208]    [Pg.343]    [Pg.69]    [Pg.186]    [Pg.23]    [Pg.55]    [Pg.564]    [Pg.135]    [Pg.66]   
See also in sourсe #XX -- [ Pg.184 ]



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Activating function

Activation function

Active functional

Functional activation

Functional activity

Functions activity

Periphery

Periphery functional

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