Functional groups oxygen-bonded

A wider variety of reaction types involving reactions at bonds to oxygen atom bearing functional groups was investigated by the same kind of methodology [30]. Reaction classification is an essential step in knowledge extraction from reaction databases. This topic is discussed in Section 10.3.1 of this book. 

If other functional groups are present and the doubly bonded oxygen is considered a substituent on a parent chain, the prefix oxo- is used. For example ... 

Acid anhydride (Section 21.1) A functional group with two acyl groups bonded to a common oxygen atom, RC02C0R. ... 

Peroxide (Section 18.1) A molecule containing an oxygen-oxygen bond functional group, ROOR or ROOM. 

Compound 14 can be dismantled in a productive fashion by ret-rosynthetic cleavage of the indicated bonds (see Scheme 4). The intermolecular attack of the amino group in 15 upon the keto function in 16 would be expected to result in the formation of the desired oxime ether after loss of a water molecule. A few functional group manipulations would then complete the synthesis of intermediate 14. A valuable structural feature of 15 is the C-2 oxygen substituent. Although this oxygen atom is not expressed in the natural product, it would certainly play an important role in our... 

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