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Introduction functional groups

One of the principal reasons for the interest in the calixarenes is their potential for serving as enzyme mimics. If they are to operate in this capacity, however, it is necessary that they carry functional groups of various types. The p-ieri-butylcalix-arenes have proved to be excellent precursors for functional group introduction, for the p-tert-butyl group is easily removed by /ram-alkylation 123). As outlined in Scheme 7, de-ieri-butylation of p-terf-butylcalix[4]arene (58) yields compound 59 which is amenable to functionalization in the p-position. For example, bromination of the tetramethyl ether of calix[4]arene (60) proceeds smoothly, affording the tetra-bromo compound 61124) which, by lithiation followed by carbonation yields the... [Pg.35]

Lemke, T. L. (1992). Review of organic functional groups Introduction to medicinal organic chemistry, 3rd ed. Lea and Febiger, Philadelphia. [Pg.214]

Lemke TL. Review of Organic Functional Groups Introduction to Medicinal Organic Chemistry. 4th ed. Philadelphia Lippincott Williams Wilkins, 2003. [Pg.102]

Functional Group Interchange 9 C-C Bond Formation 7 Heterocyclic Syntheses 2 Cycloadditions 2 Group Protection 2 Functional Group Introduction 2 Functional Group Removal 1 C-Hetero Bond Formation 1 Hetero-Hetero Bond Formation 44 Total... [Pg.184]

Figure 1 Functional group introduction and C-C bond formation using Barton esters... Figure 1 Functional group introduction and C-C bond formation using Barton esters...
Adding TEMPO appears to effectively quench protein radieals and thus exert a proteetive aetion. New compounds that release NO under visible light irradiation (nitrosamine) are reported. Further reaetions for functional group introduction or elaboration are the hydrojgramination of algmes under visible light photocatalysis and the photocatalytic acylation of amines. ... [Pg.175]

Schrewe M, Julsing MK, Biihler B, Schmid A (2013) Whole-cell biocatalysis for selective and productive C-O functional group introduction and modification. Chem Soc Rev. doi 10.1039/ C1033CS60011D... [Pg.302]

Next, an attempt was made to evaluate the quantitative importance of the various reaction schemes [19]. To this effect, a printed compilation of 1900 reactions dealing with the introduction of one carbon atom bearing a functional group [20] was analyzed and each reaction assigned manually to a corresponding reaction scheme. The results are Hsted in Table 3-3. [Pg.189]

Since (A) does not contain any other functional group in addition to the formyl group, one may predict that suitable reaction conditions could be found for all conversions into (A). Many other alternative target molecules can, of course, be formulated. The reduction of (H), for example, may require introduction of a protecting group, e.g. acetal formation. The industrial synthesis of (A) is based upon the oxidation of (E) since 3-methylbutanol (isoamyl alcohol) is a cheap distillation product from alcoholic fermentation ( fusel oils ). The second step of our simple antithetic analysis — systematic disconnection — will now be exemplified with all target molecules of the scheme above. For the sake of brevity we shall omit the syn-thons and indicate only the reagents and reaction conditions. [Pg.198]

The most difflcult pharmaceutically relevant oxidation of steroids is the introduction of a 14 -hydroxyl group. This functional group is found in heart-active steroids (cardenolides) such as digitoxigenin, which also contain a 17/J-butenolide substituent. The 14/ -hydroxyl group is easily cleaved off by dehydration and must therefore not be treated with Lewis or... [Pg.286]

Polymer Modification. The introduction of functional groups on polysdanes using the alkah metal coupling of dichlorosilanes is extremely difficult to achieve. Some polymers and copolymers with 2-(3-cyclohexenyl)ethyl substituents on siUcon have been made, and these undergo hydrogen hahde addition to the carbon—carbon double bond (94,98). [Pg.262]

Sulfation and Sulfonation. a-Olefin reactions involving the introduction of sulfur-containing functional groups have commercial importance. As with many derivatives of olefins, several of these products have appHcations in the area of surfactants (qv) and detergents. Typical sulfur reagents utilized in these processes include sulfuric acid, oleum, chlorosulfonic acid, sulfur trioxide, and sodium bisulfite. [Pg.436]

The design of potent inactivators requires the determination of the functional groups necessary for optimal binding of the inhibitor to the enzyme. Next, the regions of steric tolerance are identified that will be useful for introduction of the reactive group. The reactivity as well as the size of the reactive... [Pg.323]


See other pages where Introduction functional groups is mentioned: [Pg.342]    [Pg.212]    [Pg.630]    [Pg.222]    [Pg.222]    [Pg.291]    [Pg.3]    [Pg.155]    [Pg.242]    [Pg.120]    [Pg.176]    [Pg.329]    [Pg.62]    [Pg.155]    [Pg.61]    [Pg.285]    [Pg.342]    [Pg.212]    [Pg.630]    [Pg.222]    [Pg.222]    [Pg.291]    [Pg.3]    [Pg.155]    [Pg.242]    [Pg.120]    [Pg.176]    [Pg.329]    [Pg.62]    [Pg.155]    [Pg.61]    [Pg.285]    [Pg.421]    [Pg.154]    [Pg.102]    [Pg.103]    [Pg.139]    [Pg.48]    [Pg.133]    [Pg.241]    [Pg.384]    [Pg.502]    [Pg.256]    [Pg.116]    [Pg.338]    [Pg.322]    [Pg.34]    [Pg.258]    [Pg.77]    [Pg.129]    [Pg.309]    [Pg.71]   
See also in sourсe #XX -- [ Pg.62 ]




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Functional organic group introduction

Introduction and Interchange of Functional Groups

Introduction functions

Introduction of Non-functional Alkyl and Reactive Allyl Groups

Introduction of functional groups

Introduction of other functional groups

Introduction to Functional Groups

Introduction to Functional Groups and Alcohols

Introduction to Organic Molecules and Functional Groups

Key Concepts—Introduction to Organic Molecules and Functional Groups

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