Fructose induced insulin resistance

Lee et al. (1994) studied the metabolic effects of troglitazone on fructose-induced insulin resistance with the euglycemic hyperinsulinemic clamp technique in rats. 

Liu IM, Tzeng TF, Liou SS, Lan TW. 2007b. Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci 81 1479-1488. 

Obesity can cause insulin resistance and hepatic steatosis, which can lead to nonalcoholic steatohepatitis (NASH) in some patients (Pessayre and Fromenty 2005). Patients with NASH have an impaired ability to resynthesize ATP after a fructose challenge (Cortez-Pinto et al. 1999). Their hepatic mitochondria exhibit ultrastructural lesions with paracristaUine inclusions in megamitochondria (Caldwell et al. 1999 Sanyal et al. 2001). Patients with NASH have decreased protein expression of several mtDNA-encoded polypeptides and lower activity of respiratory complexes (Perez-Carreras et al. 2003). Thus, obesity-associated NASH combined with the administration of drugs impairing mitochondrial (3-oxidation may additively damage mitochondria to aggravate steatosis and steatohepatitis. Indeed, obesity has been shown to increase the risk of tamoxifen-induced steatosis and steatohepatitis in women (Bruno et al. 2005). 

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