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From nitriles, with Grignard reagents

The conversion of a nitrile R —CN into a ketone R —CO—R demonstrates that polarized multiple bonds other than C=0 also react with Grignard reagents, and that such reactions are synthetically useful. Esters 22 and acid chlorides can react subsequently with two equivalents of RMgX the initially formed tetravalent product from the first addition reaction can decompose to a ketone that is still reactive, and reacts with a second RMgX. The final product 23 then contains two substituents R, coming from the Grignard reagent ... [Pg.147]

Nitriles (RC=N) react with Grignard reagents (R MgBr). The reaction produc from 2-methylpropanenitrile with methylmagnesium bromide has the fol lowing spectroscopic properties. Propose a structure. [Pg.481]

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See also in sourсe #XX -- [ Pg.731 ]



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From Grignard reagents

From nitriles

Grignard reagent nitrile

Grignard reagents with nitriles

Nitriles reagents

With Grignard Reagents

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