Friedel-Crafts acylation future

Our results for the Friedel-Crafts acylation of coal (7) indicate that bituminous coal becomes extractable not only by depolymerization but also by the Introduction of long chain substituents into the coal molecules. By the substitution with long chain aliphatic groups, the separation between the aromatic structures of adjacent molecules can be Increased so that the physical attractive forces are reduced. We tried alkylation In order to make bituminous coal more extractable. Possibly In the future extracts can be obtained economically by reaction of coal with mineral oil fractions under relatively mild conditions. 

There is, however, space for future development, particularly based on the synergic cooperation between catalysis, physicochemical characterization, and engineering groups. Hopefully, along with this contribution, a multitude of new catalytic and ecoefficient Friedel-Crafts acylation reactions will be investigated, providing the instruments to develop new sustainable synthetic routes to aromatic ketones. 

The hydroxylated anthraquinone chromophore of the anthracyclines would seem an ideal candidate for synthesis through two Friedel-Crafts acylations, either in a concurrent or a stepwise manner with formation of ring C. However, the fact that the first acylation deactivates the future ring B toward further electrophilic substitution necessitates vigorous reaction conditions, and this... 

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