Friedel-Crafis reaction

If you re not sure about why this is so, or don t understand the mechanism of the Friedel-Crafis reaction, you will find help in Tedder, part 2, pages 212-215 or Norman, pages 363-370. 

SCHEME 8. Examples of Organic Name Reactions. Friedel-Crafis Alkylation... 

S. Li, H. Zhou, B. Han, F. Deng, X. Liu, L. Xiao, J. Fan, Hydrogenated mesoporous Ti02-Si02 with increased moderate strong Bronsted acidic sites for Friedel-Crafis alkylation reaction, Catal. Sci. Technol. 2 (2012) 719—721. 

Finally, Friedel-Crafis acylation reactions are also mentioned in the literature. For example, the add catalyzed acylation of anisole with benzofuran conducted in a static micromixer has been briefly described [10]. 

G. A. Olah (Ed.), Friedel-Crafis and Related Reactions, vols. /-///, Wiley Intersdence, New York, 1963-1965. 

If this explanation is correct one can suggest that the above mentioned reactions could run separately. In proving this assumption we have suceeeded unprecedentedly to carry out reductive coupling polymerization of the conjugated dicarbonyl compound benzil under the influence of the Friedel-Crafis metathesis catalytic system WCU + AlCls. In this case the quantity of the transition metal compound is less than the quantity of the Ti reagent used for... 

Also obtained by reaction of EKONOL< >, an aromatic polyester, behaves as a Friedel-Crafis acylating reagent, with fluorobenzene in triflic acid solution at 75° for 2 h (74%) or at 25° fw 18 h (67%) [922], Similar results can be obtained using hydio-flufflic acid/boron trifluoride or aluminium chloride in place of triflic add [922],... 

An alkyl group can replace a hydrogen atom of benzene in the Friedel-Crafis alkylation reaction. This reaction requires an alkyl halide, with an aluminum trihalide as the catalyst. The catalyst produces an electrophilic species, which may be a carbocation or a carbocation complexed with a counter ion. For simplicity in writing equations, we will show only the free carbocation. The reaction is commonly carried out only with alkyl bromides or alkyl chlorides. Aryl hahdes and vinyl halides do not react because the carbocations derived from these compounds do not form under usual reaction conditions. In contrast, tertiary carbocations, such as the ferr-butyl carbocation, readily form. 

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