Organic synthesis free radical reactions

For reviews of chemical approaches to radical cyclization reactions see a) Motherwell WB, Crich D (1992) Free radical chain reactions in organic synthesis, Academic Press, London, b) Giese B (1986) Radicals in organic synthesis formation of carbon-carbon bonds, Pergamon, Oxford, and c) Jasperse CP, Curran DP, Fevig TL (1991) Chem Rev 91 1237... 

The use of free-radical reactions in organic synthesis started with the reduction of functional groups. The purpose of this chapter is to give an overview of the relevance of silanes as efficient and effective sources for facile hydrogen atom transfer by radical chain processes. A number of reviews [1-7] have described some specific areas in detail. Reaction (4.1) represents the reduction of a functional group by silicon hydride which, in order to be a radical chain process, has to be associated with initiation, propagation and termination steps of the radical species. Scheme 4.1 illustrates the insertion of Reaction (4.1) in a radical chain process. 

In recent years, the introduction of modern instrumentation has changed the orientation of research in the photochemistry of carbohydrates. After the first studies of the physical properties of irradiated reaction mixtures, identification of photopro-tation of research in the photochemistry of carbohydrates. After the first studies of the physical properties of irradiated reaction mixtures, identification of photoproducts was then undertaken and finally, an increasing use of free radical reactions including photochemical ones was applied to the synthesis of complex organic ads. 

Abstract Increasing reaction speed and simplifying product purification are two major ways to improve the efficiency of organic synthesis. A new technology for high-speed solution-phase synthesis has been developed by combination of microwave heating and fluorous purification. This review describes different techniques for microwave-enhanced fluorous synthesis and their applications in Pd-catalyzed cross-coupling reactions, free-radical reactions, multicomponent reactions, and compound library synthesis. 

Free radical reactions. 2. Organic compounds - Synthesis. 

Free radical reactions have been used in organic synthesis not only for ring expansion, but also for formation of macrocyclic ketones [48] [51]. 

Togo H (2004) Advanced free radical reactions for organic synthesis. Elsevier, Amsterdam... 

For reviews, see Giese, B. Radicals in Organic Synthesis Formation of Carbon-Carbon Bonds, Pergamon, Elmsford, NY, 1986, pp. 69-77 Vogel, H. Synthesis 1970, 99 Huyser, E.S. Free-Radical Chain Reactions, Wiley, NY, 1970, pp. 152-159 Elad, D. Fortschr. Chem. Forsch. 1967, 7, 528. Hyponitrites have been used to initiate this reaction see Dang, H.-S. Roberts, B.P. Chem. Commun. 1996, 2201. 

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