Frans-cyclohexyl ring

In 1989, Krieg et al. [79] presented the crystal structure of the smectoge-nic frans-4-(as-4-cyano-cyclohexyl)cyclohexyl frans-4-n-heptylcyclohexano-ate (CCCHC). In contrast to all other substituents which are equatorially bonded in 1,4-positions to the cyclohexyl rings, the cyano group is axially attached. The molecules adopt a fully stretched conformation. Compound CCCHC has a tilted layer structure with a herringbone arrangement of layers. 

They have employed the strategy of intramolecular trans alkylation of azetidin-2-ones since C-4 substituted azetidin-2-one enolates, predominantly yield the C-3, 4-frans-diastereomer upon reaction with electrophiles, [45] thus, providing control of stereochemistry of substituents at the cyclohexyl ring (Scheme 25). 

Reduction of arenes.1 Raney nickel (Mozingo type) in combination with 2-propanol (reflux) effects reduction of aromatic rings in 2-18 hours. Naphthalene is reduced in 18 hours to tetralin (90% yield) and cis- and frans-decalin (10% yield). Anisole is reduced in 110 hours to cyclohexyl methyl ether (90% yield). Nitrobenzene is reduced quickly to aniline and then further to cyclohexylamine and cyclohexylisopropylamine. 

Cyclohexyl radicals with fran.s-annulated six-membered rings in j8,y-position show moderate... 

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