Framingham Heart Study hypertension

Further analysis of 50 years of Framingham research showed that hypertension is a powerful risk factor accounting for about 35% of atherosclerotic cardiovascular disease. Hypertension was shown to predispose powerfully to all of the major atherosclerotic cardiovascular events including coronary artery disease, stroke, peripheral arterial disease, and heart failure. An analysis of risk of cardiovascular events in subjects with hypertension in persons aged 35-64 years in a 36-year follow-up of the Framingham study showed that the age-adjusted biennial rate per 1000 for peripheral arterial disease was 10 for men and 7 for women. The age-adjusted risk ratio was 2.0 for men and 3.7 for women, and the excess risk per 1000 was 5.0 for both men and women (17). 

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