Fragmentographic technique, mass

Improvement of the Mass Fragmentographic Technique for Quantification of Tetrahydrocannabinol in Human Blood Plasma... 

The mass fragmentographic technique with stable isotopes as internal standards shows high sensitivity (in the picogram range), specificity due to the focusing on specific mass fragments, and good reproducibility in quantitative work because the internal stable isotope... 

The mass-fragmentographic techniques were used in a number of investigations, including the early measurements of dopamine and norepinephrine in rat brain [441] and its different subregions [423], as well as the determination of dopamine and... 

An important feature of capillary GC is that it is easily combined with MS. The GC-MS technique is not only the most effective method for the identification of the steroid components of complex mixtures (profiling of biological samples, impurity profiling of industrial samples), but various kinds of mass fragmentographic techniques also enable the extremely selective and sensitive quantification of the separated components. 

Hence, the sensitivity requirements for the determination of A -THC are indicated in Fig. 4. Plasma levels will obviously be modified by the amount of THC absorbed and by the rate of absorption but if levels are to be measured later than 4 hours after administration a sensitivity of 1 ng/ml is required. Such as sensitivity combined with specificity is perhaps limited to the mass fragmentographic techniques. We have so far encountered little interference in the mass fragmento graphic determination of A -THC provided redistilled solvents, particularly ethanol, and all silanized glassware are used. If interference does occur the silylation technique provides an alternative. 

We have so far encountered little interference in the mass fragmentographic determination of THC provided redistilled solvents, particularly ethanol, and all glass apparatus are used. If interference does occur, the silylation technique provides an alternative. 

The acetyl-MHPG-boronates have some MS features which make them suitable for use in the analysis by mass fragmentography of MHPG in biological samples. The mass fragmentographic (MF) technique is the most recent advance in the analysis of monoamine metabolites. Examples of studies by this technique are those in ventricular fluid (24), in urine, plasma, CSF and tissues (25) and in amniotic fluid (26), In those studies the molecular ion or others which are typical of the parent molecule are monitored. 

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