Fragment screening advantages

Neumann, T., Junker, H. D., Schmidt, K., Sekul, R. (2007) SPR-based fragment screening advantages and applications. Curr Top Med Chem 7, 1630-1642. 

Schade, M. NMR fragment screening advantages and applications. IDmgs 2006, 9, 110-113. 

While most pharmaceutical and biotech companies utilize high-throughput screening (HTS) as their primary assay, FBLD offers numerous advantages. Compared with HTS, there is significantly fewer compounds to be screened. There are typically thousands of compounds for a fragment screen versus hundreds... 

In this review, an approach is described that overcomes these difficulties using biophysical methods. The advantages and limitations of the various technologies are discussed in some detail in order to give guidance for the selection of the most appropriate methods for fragment screening [12]. The main focus, however, is on a detailed description of how to use SPR-based methods. 

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