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Fragment capture reversible, tethering

Researchers at Sunesis pharmaceuticals have developed a fragment-based drug discovery method termed tethering [25]. The approach, which is illustrated in Scheme 2.6, shares a number of features with DCC. Whereas protein-directed DCLs equilibrate small molecules via disulfide formation, say, in the presence of a protein that acts as a thermodynamic trap, tethering uses a cysteine residue on the protein surface to reversibly capture small-molecule thiol fragments from solution. Tethering is designed... [Pg.62]


See other pages where Fragment capture reversible, tethering is mentioned: [Pg.306]    [Pg.219]    [Pg.256]    [Pg.171]    [Pg.124]    [Pg.124]    [Pg.3047]   


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Fragment capture

Tether

Tethering

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