Ligands fragment-based discovery

Fischer M, Hubbard RE (2009) Fragment-based ligand discovery. Mol Interv 9( 1) 22—30... [Pg.82]

Over B, Wetzel S, Grutter C, Nakai Y, Renner S, Rauh D, Waldmann H (2012) Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem 5 21-28 International network of food data systems, http //www.fao.org/infoods/infoods/en/. Accessed 7 Sept2014... [Pg.150]

Keywords VS, Virtual Screening, Lead discovery, lead, HTS, Pharmacophore-Based, Structure-Based, Fragment-based, Ligand-based, Docking, Scoring, hybrid workflows, VS strategy, Benchmarking VS... [Pg.85]

Fragment-Based Ligand Design Puzzling Approaches to Drug Discovery.126... [Pg.125]

Chen Y, Shoichet BK (2009) Molecular docking and ligand specificity in fragment-based inhibitor discovery. Nat Chem Biol 5 358-364... [Pg.25]

Fruh V, Zhou Y, Chen D et al (2010) Application of fragment-based drug discovery to membrane proteins identification of ligands of the integral membrane enzyme DsbB. Chem Biol 17 881-891... [Pg.28]

Bembenek SD, Tounge BA, Reynolds CH (2009) Ligand efficiency and fragment-based drug discovery. Drug Discov Today 14 278-283... [Pg.30]

Murray CW, Carr MG, Callaghan O et al (2010) Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency. J Med Chem 53 5942-5955... [Pg.31]

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