Fragility implications

Finally, this section has focused almost entirely on axonal transport, but dendritic transport also occurs [25]. Since dendrites usually include postsynaptic regions while most axons terminate in presynaptic elements, the dendritic and axonal transport each receive a number of unique proteins. An added level of complexity for intraneuronal transport phenomena is the intriguing observation that mRNA is routed into dendrites where it is implicated in local protein synthesis at postsynaptic sites, but ribosomal components and mRNA are largely excluded from axonal domains [26]. Regulation of protein synthesis in dendritic compartments is an important mechanism is synaptic plasticity [27,28]. The importance of dendritic mRNA transport and local protein synthesis is underscored by the demonstration that the mutation associated with Fragile X syndrome affects a protein important for transport and localization of mRNA in dendrites [27, 29], Similar processes of mRNA transport have been described in glial cells [30]. 

Le Beau MM, Rassool FV, Neilly ME, Espinosa R 3rd, Glover TW, Smith DI, McKeithan TW. Replication of a common fragile site, ERA3B, occurs late in S phase and is delayed further upon induction implications for the mechanism of fragile site induction. Hum. Mol. Genet. 1998 7 755-761. 

The implication of making H as small as possible is that the thermal detector should be as small and of as light a construction as practicable. This is the reason for the fragile and delicate nature of many types of thermal detector. One of the reasons for the large amount of interest in the current developments of the pyroelectric detector is that (as we shall see in Sect. 3.5) it offers a way round this dilemma of achieving both sensitivity and robustness. 

The information contained in qubits and entangled states includes the phase any error in the phase has important implications (e.g., changing an entangled to a product state). To perform complex quantum computations, we need to reliably prepare a delicate superposition of states of a relatively large quantum system, which cannot be perfectly isolated from the environment hence the superpositions always decay. The decoherence of an entangled state is even faster the nonlocal correlations are extremely fragile and decay very rapidly. Also, applications of unitary transformations to qubits will not be flawless, and errors can accumulate. 

CoUinson, S., etal. (2010) States of Fragility StabUisation and its Implications for Humanitarian Action. Humanitarian Policy Group Working Paper, Overseas Development Institute, August... 

The fragile nature of the particles of carbonate sands and their tendency to cement together may also have its implications for the laboratory testing. 

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