Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Similar to cembranolide, clavaric acid was competitive with respect to the Ras-peptide substrate Kj = 1.4 jM) and non- and/or un-competitive with FPP despite having a negatively charged carboxyl group. This is only the second example of a non-nitrogenous FPTase inhibitor that is competitive with peptide substrate. These two (cembranolide and clavaric acid) structurally distinct compounds show remarkably similar profiles of the mechanism of FPTase inhibition [117]. [Pg.441]

See other pages where FPTase inhibition is mentioned: [Pg.404] [Pg.427]

See also in sourсe #XX -- [ Pg.24 , Pg.444 ]