Fosamax Plus D

Fosamax plus D) 10 mg daily, 70 mg tablet 70 mg tablet with vitamin intake-long T1/2 (<10 years) ... 

Alendronate (Fosamax, Fosamax Plus D) Raloxifene (Evista)... 

Uses Rx prevent osteoporosis male female, Rx steroid-induced osteoporosis, Paget Dz Action -1- N1 abnormal bone resorption Dose Osteoporosis Rx 10 mg/d PO or 70 mg qwk Fosamax plus D 1 tab qwk Steroid-induced osteoporosis Rx 5 mg/d PO Prevention 5 mg/d PO or 35 mg qwk Paget Dz 40 mg/d PO Caution [C, ] Not OK if CrCl <35 mLAnin, w/ NSAID use Contra Esophageal anomalies, inability to sit/stand upright for 30 min, X Ca Disp Tabs, soln SE GI disturbances, esophageal irritation, HA, pain, jaw osteonecrosis (w/ dental procedures, chemo) Interactions -1- Absorption W7 antacids, Ca supls, Fe, food T risk of upper GI bleed W/ ASA NSAIDs EMS May cause cardiac conduction abnormalities d/t T Ca T risk of jaw fractures esp w/ dental procedures OD May cause hypocalcemia and adverse upper-GI effects milk or antacids can be given to bind alendronate... 

A new formulation of alendronate, FOSAMAX PLUS D, was approved by the U.S. FDA in April 2005. This formulation includes 70 mg of alendronate and 2,800 lU of vitamin D3 (i.e., a 7-day supply of both the bisphosphonate and vitamin D). This formulation should not be used in patients with severe kidney disease or low serum calcium levels and should not be the only therapy used to correct a vitamin D deficiency. 

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